陳大方

慢性病分子流行病學、醫學科研數據挖掘

1.腫瘤病人的免疫狀態評估(北京市科委重大科技項目，2002-2006，子課題負責人)。

2.低出生體重的分子遺傳流行病學研究(國家計生委重大攻關課題🙆🏽‍♀️，2000-2004,課題負責人)🌡。

3.抑郁症早期診斷方法和標準化綜合治療模式的研究（國家十一五項目🎇，2008—2012👷🏽💆🏿，子課題負責人）。

4.重大慢性非傳染性疾病風險評估與預測（國內合作項目，2012-2016🧛🏿‍♂️，課題承擔人）🧏🏽。

5.北京市房山區成人2型糖尿病發病風險模型的建立與評估（國家自然基金面上項目，2012-2015🦂🥯，課題承擔人）。

6.重大慢性疾病風險預測、早期風險篩查、個性化健康管理和亞健康重點人群動態隊列建設技術服務（國內合作項目，2014-2019🧼，課題承擔人）🤹🏼‍♂️。

7.中國急性心肌梗死救治項目指標體系建立與評估（中國醫師協會合作項目，2016-2018，子課題承擔人）。

8.EPICOR Asia急性冠脈綜合征中國延長隨訪研究（阿斯利康中國合作項目🤜，2017-2019，子課題承擔人）🎹。

9.基於患病不一致同胞對代謝綜合征的基因多效性研究（北京市自然基金面上項目，2018-2020，課題承擔人）。

10.基於家系研究設計的2型糖尿病發病遺傳培育效應研究（國家自然基金面上項目𓀑，2019-2022💁🏼‍♀️🏊🏽‍♀️，課題承擔人）。

1.Jun Zhang,  Feng Zhou, Xu Ran,  Ping Ye, Si Chen, Xiaotong Dai, Dafang Chen, Baoguo Jiang. Reliability and validity an indicator system used to evaluate outpatient and inpatient satisfaction in Chinese hospitals.Patient Preference and Adherence. 2018:12. 2527–2536.

2.Qiwen Zheng, Hui Liu, Jun Zhang, Dafang Chen. The Effect of Ambient Particle Matters on Hospital Admissions for Cardiac Arrhythmia: A multi-city case-crossover study in China. Environmental Health, 2018 Jul 16;17(1):60. doi: 10.1186/s12940-018-0404-z. 

3.Xiaotong Dai, Hui Liu, Dafang Chen, Jun Zhang. Association between ambient particulate matter concentrations and hospitalization for ischemic heart disease (I20-I25, ICD-10) in China: A multicity case-crossover study. Atmospheric Environment 186 (2018) 129–135. 

4.Si Chen, Ying Yang, Guan-Liang Cheng, Jia Jia, Fang-Fang Fan,Jian-Ping Li,Yong Huo, Yan Zhang, Da-Fang Chen. Association between short sleep duration and carotid atherosclerosis in Chinese Community Population. J Epidemiol Community Health.  2018 Jun;72(6):539-544. 

5.Keye Wu， Aiqun Huang， Si Chen🤘🏿， Wei Zhao， Huanqing Hu📢， Qi Yang; Dafang Chen. Arrendance at prenatal care and adverse birth outcomes in China: a follow-up study based on Maternal and Newborn’s Health Monitoring System. Midwifery,  57（2018）26-31.

6.Xiaozhu Wang, Yu Huang, Ming Yan, Jiuwei Li, Changhong Ding, Hong Jin, Fang Fang, Yanling Yang, Baiyan Wu, Dafang Chen. Molecular spectrum of excision repair cross-complementation group 8 gene defects in Chinese patients with Cockayne syndrome type A. Scientific Reports 7, Article number: 13686 (2017) doi:10.1038/s41598-017-14034-3.

7.Liu ZK, Wu KY, Dai XT, Che QZ, Chen S, Jia J2, Li JP, Huo Y, Zhang Y, Chen DF. The grading effect of abnormal glucose status on arterial stiffness and a new threshold of 2-hour post-load glucose based on a Chinese community study.J Diabetes Investig. 2017 Sep 1. doi: 10.1111/jdi.12741.

8.Duan F, Guo Y, Zhang L, Chen P, Wang X, Liu Z, Hu Y, Chen S, Chen D. Association of KCNQ1 polymorphisms with gliclazide efficacy in Chinese type 2 diabetic patients. Pharmacogenetics and Genomics. 26(4):178–183, APR 2016.

9.Liu-wei ZHANG, Jian-ping LI, Fang-fang DUAN, Zhi-ke Liu, Zi-qing Ma, Jin LI, Jie Jiang, Yan Zhang, Yong HUO, Da-fang CHEN. Synergistic effect of type 2 diabetes mellitus with Chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case-control study in Chinese population. BMC Cardiovascular Disorders. 2014,14:170.

10.Di-Qing Luo, Xiao-Zhu Wang, Yan Meng, Ding-Yang He, Ying-Ming Chen, Zhi-Yong Ke, Ming Yan,Yu Huang and Da-Fang Chen. Mandibuloacral dysplasia type A-associated progeria caused by homozygous LMNA mutation in a family from Southern China. BMC Pediatrics 2014, 14:256.