趙鵬

細胞與分子毒理學🧔🏻‍♂️、化學致癌作用、毒物基因組學、靶器官毒理學。

1. 國家重點研發計劃課題，2017YFC1600203，基於毒作用機製和健康效應終點的食品稀土元素和添加劑的安全性評估，2018.01~2021.12🍨，項目骨幹。

2. 國家自然科學基金面上項目（青年-面上連續資助項目），81370079，基於細胞應激反應途徑組合測試和毒物基因組學預測化學物肝、腎靶器官毒性，2014.01~2017.12🫎，項目負責人。

3. 北京市自然科學基金面上項目，7132122👭，基於BaP惡性轉化16HBE細胞成瘤裸鼠血清蛋白質組學篩選腫瘤生物標誌，2013.01~2015.12，項目負責人。

4. 國家自然科學基金青年科學基金項目💅🏿，81001253，毒物細胞應激反應途徑識別和肝💼、腎靶器官毒性預測，2011.01~2013.12，項目負責人💂🏽‍♂️。

5. 新型溶瘤病毒（BioTTT001）單次腹腔內註射給予荷瘤金黃地鼠的組織分布研究，2020.7~2021.1☔️，項目負責人👢。

6. 可表達PD-1多肽的新型溶瘤腺病毒臨床前體內藥效學研究，2021.9~2022.3🍫，項目負責人。

1. Zhou C, Ma X, Chen J, Li L, Wang Y, Xing Y, Fu J, Yao B, Chang B*, Zhao P*. Untargeted metabolomics and lipidomics analysis identified the role of FOXA1 in remodeling the metabolic pattern of BaP-transformed 16HBE cells. Toxicol Appl Pharmacol. 2021; 426: 115640.

2. Wang Y‖, Li L‖, Hao M, Fu D, Chen J, Zhou C, Fu J, Yao B, Chang B*, Zhao P*. Label-free quantitative proteomic analysis identifies the oncogenic role of FOXA1 in BaP-transformed 16HBE cells. Toxicol Appl Pharmacol. 2020; 403: 115160.

3. Li L, Chen J, Wang Y, Zhou C, Ma X, Fu J, Yao B, Zhao P*. MicroRNA expression profiling and the role of ALCAM modulating tumor growth and metastasis in benzo[a]pyrene-transformed 16HBE cells. Toxicology. 2020; 442: 152539.

4. Wang Y‖, Jia Y‖, Yan L, Fu J, Hao M, Chen W, Yao B, Zhao P*, Zhou Z*. Clusterin and neuropilin-2 as potential biomarkers of tumor progression in benzo[a]pyrene-transformed 16HBE cells xenografted nude mouse model. Chem Biol Interact. 2017; 275: 145-151.

5. Zhao P*, Fu J, Yao B, Jia Y, Zhang H, Li X, Dong L, Gao Y, Liu W, Chen W, Zhou Z*. Label-free quantitative proteomic analysis of benzo(a)pyrene-transformed 16HBE cells serum-free culture supernatant and xenografted nude mice sera. Chem Biol Interact. 2016; 245: 39-49.

6. Zhao P, Fu J, Yao B, Song Y, Yuan L, Jia Y, Ma S, Chen W, Zhou Z*. The cell cycle distribution should be given more consideration in cell-based in vitro toxicological studies. Arch Toxicol. 2014; 88: 337-343.

7. Zhao P, Fu J, Yao B, Hu E, Song Y, Mi L, Li Z, Zhang H, Jia Y, Ma S, Chen W, Zhou Z*. Diethyl sulfate-induced cell cycle arrest and apoptosis in human bronchial epithelial 16HBE cells. Chem Biol Interact. 2013; 205: 81-89.

8. Zhao P, Fu J, Yao B, Song Y, Mi L, Li Z, Shang L, Hao W*, Zhou Z*. In vitro malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene. Toxicol In Vitro. 2012; 26: 362-368.

9. Zhao P‖, Zhang L‖, Zhong W, Ying X, Huang H, Yao B, Yuan Z, Fu J, Wang Y, Zhou Z*. Antigen-subtracted 2-DE/MS strategy, a novel proteomic analysis platform. Arch Toxicol. 2011; 85: 35-41.

10. Zhao P, Zhong W, Ying X, Yuan Z, Fu J, Zhou Z*. Manganese chloride-induced G0/G1 and S phase arrest in A549 cells. Toxicology. 2008; 250:39-46.